The degradation of taurocholic acid and glycocholic acid by Pseudomonas spp. N.C.I.B. 10590.
نویسندگان
چکیده
Reports on the microbial degradation of bile-acid conjugates have been mainly limited to observations of hydrolytic cleavage yielding free bile acids. Clostridium spp., Enterococcus spp. (Norman & Grubb, 1955), Bacteroides spp., BiJdobacteria spp. (Drasar & Hill, 1966) and species of rat intestinal bacteria (Dickinson et a/., 1971) were all shown to deconjugate bile-acid conjugates under anaerobic conditions yielding free bile acids:
منابع مشابه
The degradation of cholic acid by Pseudomonas sp. N.C.I.B. 10590.
The microbial degradation of cholic acid by Pseudomonas sp. N.C.I.B. 10590 was studied, and two major products were isolated and identified as 7 alpha, 12 beta-dihydroxyandrosta-1,4-diene-3,17-dione and 7 alpha, 12 alpha-dihydroxy-3-oxopregna-1,4-diene-20-carboxylic acid. Four minor products were isolated and evidence is given for the following structures: 7 alpha, 12 alpha-dihydroxyandrosta-1,...
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Pseudomonas spp. capable of using sodium deoxycholate as the sole carbon source were isolated from faeces, sewage and soil by enrichment culture in a defined medium. An isolate, designated Pseudomonas N.C.I.B. 10590, oxidized deoxycholic acid during aerobic growth to yield metabolites with the 1,4-diene3-one structure; this oxidation also occurred anaerobically if nitrate was present. The nucle...
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The biotransformation of lithocholic acid by Pseudomonas sp. strain NCIB 10590 under anaerobic conditions was studied. The major products were identified as androsta-1,4-diene-3,17-dione and 3-oxochol-4-ene-24-oic acid. The minor products included 17beta-hydroxyandrost-4-ene-3-one, 17beta-hydroxyandrosta-1,4-diene-3-one, 3-oxo-5beta-cholan-24-oic acid, 3-oxochola-1,4-diene-24-oic acid, 3-oxopre...
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 6 5 شماره
صفحات -
تاریخ انتشار 1978